PEG conjugated BODIPY-Br2 as macro-photosensitizer for efficient imaging-guided photodynamic therapy. Issue 5 (18th January 2018)

• Record Type: Journal Article
• Authors: Ruan, Zheng; Zhao, Yangyang; Yuan, Pan; Liu, Le; Wang, Yucai; Yan, Lifeng
• Is Part Of: Journal of materials chemistry. Volume 6:Issue 5(2018)
• Page Start: 753
• Page End: 762
• Publication Date: 2018-01-18
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c7tb02924a
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : PEG-BDP macro-photosensitizer was synthesized which showed imaging-guided photodynamic therapy. Abstract : Drug-free biocompatible nanoparticles with photosensitizers as both diagnostic and therapy agents represent an emerging approach for imaging-guided photodynamic therapy (PDT). Here, a NSH-active boron-dipyrromethene (BODIPY) derivative with a bromine substituted (BODIPY-Br2, for simplicity, BDP-Br ) photosensitizer was synthesized; it showed a high ability of generating reactive oxygen species (ROS) upon irradiation for PDT and near infrared fluorescence imaging ability. Then, a simple PEGylatedBDP-Br (PEG-BDP ) as a kind of macro photosensitizer was prepared which showed superior cellular uptake ability, high efficiency of imaging, and curing with PDT therapy in vitro and in vivo . After administration with a 4T1 orthotopic tumor model, the resultantPEG-BDP showed prolonged blood circulation and preferential tumor accumulation compared with freeBDP-Br molecules. Once accumulated in tumor tissues, therapeutic effects ofPEG-BDP could significantly suppress primary tumor growth and has no evident side effects at a weak irradiation energy as low as 35 mW cm −2 for 20 minutes. The designation of this simple structure macro photosensitizer agent provides new avenues for efficient imaging-guided cancer PDT.