Relationship between Hippocampal Subfields and Category Cued Recall in AD and PDD: A Multimodal MRI Study. (10th February 2018)

• Record Type: Journal Article
• Authors: Novellino, Fabiana; Vasta, Roberta; Sarica, Alessia; Chiriaco, Carmelina; Salsone, Maria; Morelli, Maurizio; Arabia, Gennarina; Saccà, Valeria; Nicoletti, Giuseppe; Quattrone, Aldo
• Is Part Of: Neuroscience. Volume 371(2018)
• Page Start: 506
• Page End: 517
• Publication Date: 2018-02-10
• Subjects: AD Alzheimer's disease -- BDI-II beck depression inventory II -- CA cornu ammonis -- COWAT controlled oral word association test -- DFR delayed free recall -- DG dentate gyrus -- DTI diffusion tensor imaging -- DTR delayed total recall -- F fimbria -- FA fractional anisotropy -- FAB frontal assessment battery -- FCRST free and cued selective remanding test -- HAMA hamilton anxiety rating scale -- HC healthy controls -- HF hippocampal fissure -- IFR immediate free recall -- ISC index of sensitivity of cueing -- ITR immediate total recall -- JLOV judgement of lines orientation-V -- MCST (CA) modified card sorting test (correct answers) -- MD mean diffusivity -- MMSE mini-mental state examination -- MRI magnetic resonance imaging -- PDD Parkinson's disease with dementia -- RAVLT (I and D) Rey auditory verbal learning test (immediate and delayed recall) -- TH temporal horn -- UPDRS-ME unified Parkinson's disease rating scale motor examination; Alzheimer's disease -- Parkinson's disease dementia -- hippocampal subfields -- FCSRT -- episodic memory -- multimodal MRI; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2017.12.028
• Languages: English
• ISSNs: 0306-4522

Abstract

Highlights: We investigated how hippocampal changes relate to memory cued recall in AD and PDD. We performed a multimodal hippocampal MRI study and a memory evaluation trough FCSRT. Hippocampal subfields showed different vulnerability to damage related to AD and PDD. CA1, CA4-DG and subiculum were the subfields differently involved in AD and PDD. CA1, CA4-DG and subiculum were related to total recall items of FCSRT in AD group. Abstract: Alzheimer's disease (AD) and Parkinson's disease with dementia (PDD) are characterized by a different mnesic failure, particularly in memory cued recall. Although hippocampal involvement has been shown in both these diseases, it remains unknown whether a selective damage of specific subfields within the hippocampus may be responsible for the peculiar mnesic profile observed in AD and PDD. To explore this topic, we combined a multimodal 3 T-MRI hippocampal evaluation (whole-brain T1-weighted and diffusion tensor imaging) with a hippocampal-targeted neuropsychological assessment (Free and Cued Selective Reminding Test [FCSRT]) in 22 AD subjects, 18 PDD and 17 healthy controls. Macro- and microstructural features (volume; shape; mean diffusivity [MD]; fractional anisotropy [FA]) of bilateral hippocampi (whole and subfields) were obtained. Correlations between MRI-derived parameters and neuropsychological evaluations were performed. In the comparison between AD and PDD, the multimodal analysis allowed us to identify that subiculum, CA1 and CA4-DG were differently involved in these diseases and correlated with immediate and delayed total recall items of FCSRT. Moreover, compared to controls, AD showed a reduction in almost all subfields, with a MD increase in the same regions, whereas PDD displayed a volume loss, less severe than AD, more evident in the CA2-3 and presubiculum subfields. Our study provides new evidence that hippocampal subregions had different vulnerability to damage related to AD and PDD. The combination of the in vivo analysis of hippocampal subfields with the FCSRT paradigm provided important insights into whether changes within specific hippocampal subfields are related to the different mnesic profile in AD and PDD patients.