Effects of the brain-derived neurotropic factor variant Val66Met on cortical structure in late childhood and early adolescence. (March 2018)

• Record Type: Journal Article
• Authors: de Araujo, Celia Maria; Zugman, Andre; Swardfager, Walter; Belangero, Sintia Iole Nogueira; Ota, Vanessa Kiyomi; Spindola, Leticia Maria; Hakonarson, Hakon; Pellegrino, Renata; Gadelha, Ary; Salum, Giovanni Abrahão; Pan, Pedro Mario; de Moura, Luciana Monteiro; Del Aquilla, Marco; Picon, Felipe Almeida; Amaro, Edson; Sato, João Ricardo; Brietzke, Elisa; Grassi-Oliveira, Rodrigo; Rohde, Luis Augusto P.; Miguel, Euripedes Constantino; Bressan, Rodrigo A.; Jackowski, Andrea Parolin
• Is Part Of: Journal of psychiatric research. Volume 98(2018)
• Page Start: 51
• Page End: 58
• Publication Date: 2018-03
• Subjects: Brain-derived neurotrophic factor -- BDNF -- rs6265 -- Val66Met -- Children -- Adolescents -- Psychiatric disorders -- Brain morphology -- MRI -- Cortical thickness; Psychiatry -- Periodicals; Mental Disorders -- Periodicals; Maladies mentales -- Périodiques; Psychiatry; Electronic journals; Periodicals; 616.89005
• DOI: 10.1016/j.jpsychires.2017.12.008
• Languages: English
• ISSNs: 0022-3956

Abstract

Abstract: Background: The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism ( rs6265 ) has been associated with several neuropsychiatric disorders and regional structural brain changes in adults, but little is known about Val66Met 's effect on brain morphology during typical or atypical neurodevelopment. Windows of vulnerability to psychopathology may be associated with the different alleles of the Val66Met polymorphism during childhood and adolescence. Methodology: We investigated the effect of Val66Met on cortical thickness in MRI scans of 718 children and adolescents (6–12 years old) with typical development, and in those meeting DSM criteria for a psychiatric disorder. Results: Val66Met had a significant effect on cortical thickness. Considering the typically developing group, Met-carriers presented thicker parietal and occipital lobes and prefrontal cortices compared to Val homozygotes. Met-carriers with psychiatric disorders presented thicker medial and lateral temporal cortices than Val homozygotes. Furthermore, a significant genotype × psychiatric diagnosis interaction was found: Met-carriers with a psychiatric diagnosis presented thinner bilateral prefrontal cortices than Val homozygotes. Conclusion: This study provides evidence that Val66Met is associated with cortical maturation in children and adolescents with and without psychiatric disorders.