Addendum to Aniline [BAT Value Documentation 2015]. Issue 2 (28th April 2017)

• Record Type: Journal Article
• Authors: Bolt, H.M.; Leng, G.; Drexler, H.; Hartwig, A.
• Is Part Of: MAK collection for occupational health and safety. Volume 2:Issue 2(2017)
• Page Start: 1032
• Page End: 1038
• Publication Date: 2017-04-28
• Subjects: aniline -- aminobenzene -- phenylamine -- occupational exposure -- biological tolerance value -- BAT value -- BLW -- toxicity; Biological monitoring -- Periodicals; Industrial toxicology -- Periodicals; Hazardous substances -- Periodicals; 615.902
• DOI: 10.1002/3527600418.bb6253e2217
• Languages: English
• ISSNs: 2509-2383

Abstract

Abstract: The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the BAT value (biological tolerance value) for aniline, considering aniline in urine to characterise the internal exposure and the methaemoglobin formation as critical effect. Available publications as well as unpublished study reports are described in detail. In a new chamber study, 19 individuals were exposed to the present MAK‐value of 2 ml 3 for 6 hours with defined physical activity. The background level of methaemoglobin was 0.7 ± 0.2%. At the end of exposure, an increase of up to 1.2 ± 0.3% (range 0.8–2.1%) was observed. The mean excretion of aniline in urine after hydrolysis at the end of exposure was 168 ± 52 µg/l (range 79.5–418 µg/l). The BAT‐value relates to an air concentration of 2 ml/m 3 and a methaemoglobin level of 5%. Considering this study, a BAT‐value of 500 µg aniline (after hydrolysis)/l urine was evaluated. This value is a maximum concentration because of acute toxic effects of methaemoglobin. Sampling time is at the end of exposure or the end of the working shift. For the hemoglobin adduct of aniline, a BLW ("Biologischer Leitwert") of 100 µg aniline (released from aniline‐haemoglobin conjugate)/l blood was evaluated based on occupational‐medical experiences in field studies.