Addendum to Methyl bromide [BAT Value Documentation 2014]. Issue 2 (25th April 2017)

• Record Type: Journal Article
• Authors: Hallier, E.; Müller, M.; Drexler, H.; Hartwig, A.
• Is Part Of: MAK collection for occupational health and safety. Volume 2:Issue 2(2017)
• Page Start: 1053
• Page End: 1058
• Publication Date: 2017-04-25
• Subjects: methyl bromide -- bromomethane -- monobromomethane -- occupational exposure -- biological tolerance value -- BAT value -- BLW -- EKA -- toxicity; Biological monitoring -- Periodicals; Industrial toxicology -- Periodicals; Hazardous substances -- Periodicals; 615.902
• DOI: 10.1002/3527600418.bb7483e2217
• Languages: English
• ISSNs: 2509-2383

Abstract

Abstract: The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the BLW ("Biologischer Leitwert") for methyl bromide, using bromide in serum/plasma to characterise the internal exposure. The critical effect of methyl bromide is a high acute and chronic neurotoxicity. It can pass through the skin so that biological monitoring is highly recommended. On the basis of results of a human study the occurrence of abnormal findings in the EEG is comparable for unexposed persons and persons with exposure to methyl bromide in concentrations below 12 mg bromide/l plasma. Thus the BLW of 12 mg bromide/l plasma or serum was confirmed. The sampling time for long‐term exposure is at the end of exposure/shift after several previous shifts. The evaluation of an EKA for methyl bromide in the air and S‐methylcysteine‐albumin adducts in blood is not possible as there is insufficient data available.