Oleanane-type triterpenoid saponins from Lysimachia fortunei Maxim. (March 2018)

• Record Type: Journal Article
• Authors: Zhang, Shu-Lin; Yang, Zi-Ni; He, Cui; Liao, Hai-Bing; Wang, Heng-Shan; Chen, Zhen-Feng; Liang, Dong
• Is Part Of: Phytochemistry. Volume 147(2018)
• Page Start: 140
• Page End: 146
• Publication Date: 2018-03
• Subjects: Lysimachia fortunei Maxim -- Myrsinaceae -- Triterpenoid saponins -- Cytotoxic activities; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2017.12.022
• Languages: English
• ISSNs: 0031-9422

Abstract

Abstract: Six previously undescribed oleanane-type triterpenoid saponins, fortunosides A–F, together with six known ones, were isolated from the aerial parts of L ysimachia fortunei Maxim. Their structures were established by spectroscopic data analyses (1D, 2D-NMR and HRESIMS) and chemical methods. All isolated triterpenoid saponins were evaluated for their cytotoxicity against four human liver cancer cell lines (SMMC-7721, Hep3B, HuH7, and SK-Hep-1). Three saponins with the aglycone protoprimulagenin A exhibited moderate cytotoxicity against all of the tested human cancer cell lines, with IC50 values ranging from 4.76 to 15.12 μM. Graphical abstract: Twelve oleanane-type triterpenoid saponins, including six previously undescribed ones, were isolated from the aerial parts of L ysimachia fortunei Maxim. Three saponins with the aglycone protoprimulagenin A exhibited moderate cytotoxicity against all of the tested human liver cancer cell lines. Highlights: Six previously undescribed triterpenoid saponins were isolated from Lysimachia fortunei. Their structures were elucidated by spectrometric data analyses and chemical methods. Saponins with the aglycone protoprimulagenin A exhibited moderate cytotoxicity.