Determining the best percent-predicted equation for estimated VO2 peak by a 1-km moderate perceptually-regulated treadmill walk to predict mortality in outpatients with cardiovascular disease. Issue 3 (March 2018)

• Record Type: Journal Article
• Authors: Grazzi, Giovanni; Mazzoni, Gianni; Myers, Jonathan; Codecà, Luciano; Pasanisi, Giovanni; Mandini, Simona; Piepoli, Massimo; Volpato, Stefano; Conconi, Francesco; Chiaranda, Giorgio
• Is Part Of: Journal of science and medicine in sport. Volume 21:Issue 3(2018)
• Page Start: 307
• Page End: 311
• Publication Date: 2018-03
• Subjects: Exercise test -- Oxygen consumption -- Predictive value of tests -- Secondary prevention; Sports sciences -- Periodicals; Sports medicine -- Periodicals; Exercise -- Physiological aspects -- Periodicals; Sports -- physiology -- Periodicals; Sports Medicine -- Periodicals; Sportgeneeskunde; 617.102705
• DOI: 10.1016/j.jsams.2017.06.003
• Languages: English
• ISSNs: 1440-2440

Abstract

Abstract: Objectives: To determine the prognostic ability of established percent-predicted equations of peak oxygen consumption (%PRED) estimated by a moderate submaximal walking test in a large cohort of outpatients with cardiovascular disease (CVD). Design: Population-based prospective study. Methods: A total of 1442 male patients aged 25–85 years at baseline, underwent a moderate perceptually-regulated (11–13 on the 6–20 Borg scale) treadmill walk (1k-TWT) for peak oxygen consumption estimation (VO2 peak). %PRED was derived from ACSM, Ades et al, Morris et al, and the Wasserman/Hansen equations, and their prognostic performance was assessed. Overall mortality was the end point. Participants were divided into quartiles of %PRED, and mortality risk was estimated using a Cox regression model. Results: During a median 8.2 year follow-up, 167 all-cause deaths occurred. The Wasserman/Hansen equation provided the highest prognostic value. Mortality rate was lower across increasing quartiles of %PRED. Compared to the first quartile, after adjustment for confounders, the mortality risk decreased for the second, third, and fourth quartiles, with HRs of 0.75 (95% CI 0.44–1.29, p = 0.29), 0.67 (95% CI 0.38–1.18, p = 0.17), and 0.37 (95% CI 0.10–0.78, p = 0.009), respectively (p for trend <0.0001). Each 1% increase in %PRED conferred a 4% improvement in survival. Conclusions: The percent-predicted VO2 peak determined by Wasserman/Hansen equations applied to the 1k-TWT is inversely and significantly related to survival in cardiac outpatients. The 1k-TWT is a simple and useful tool for stratifying mortality risk in patients participating in secondary prevention programs.