The exomic landscape of t(14;18)‐negative diffuse follicular lymphoma with 1p36 deletion. (28th November 2017)

• Record Type: Journal Article
• Authors: Zamò, Alberto; Pischimarov, Jordan; Horn, Heike; Ott, German; Rosenwald, Andreas; Leich, Ellen
• Is Part Of: British journal of haematology. Volume 180:Number 3(2018)
• Page Start: 391
• Page End: 394
• Publication Date: 2017-11-28
• Subjects: follicular lymphoma -- exome -- 1p36 -- diffuse -- STAT6; Hematology -- Periodicals; Blood -- Diseases -- Periodicals; 616.15
• DOI: 10.1111/bjh.15041
• Languages: English
• ISSNs: 0007-1048

Abstract

Summary: Predominantly diffuse t(14;18) negative follicular lymphoma (FL) with 1p36 deletion shows distinctive clinical, morphological and molecular features that distinguish it from classical FL. In order to investigate whether it possesses a unique mutation profile, we performed whole exome sequencing of six well‐characterised cases. Our analysis showed that the mutational landscape of this subtype is largely distinct from classical FL. It appears to harbour several recurrent mutations, affecting STAT6, CREBBP and basal membrane protein genes with high frequency. Our data support the view that this FL subtype should be considered a separate entity from classical FL.