Triterpenoid saponins from the pulp of Sapindus mukorossi and their antifungal activities. (March 2018)

• Record Type: Journal Article
• Authors: Hu, Qingwen; Chen, Ying-Ying; Jiao, Qi-Yang; Khan, Afsar; Li, Feng; Han, De-Feng; Cao, Gui-Dong; Lou, Hong-Xiang
• Is Part Of: Phytochemistry. Volume 147(2018)
• Page Start: 1
• Page End: 8
• Publication Date: 2018-03
• Subjects: Sapindus mukorossi -- Sapindaceae -- Triterpenoid saponins -- Anti-fungal activity; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2017.12.004
• Languages: English
• ISSNs: 0031-9422

Abstract

Abstract: Under the guidance of anti-fungal bioassay, four previously undescribed oleanane-type and one lupane-type triterpenoid saponins, along with twelve known analogues, were isolated from the extract of Sapindus mukorossi pulps. Their structures were determined on the basis of spectroscopic analysis and chemical methods. In vitro biotests, oleanolic acid 3- O - β -D-xylopyranosyl-(1 → 3)- α -L-rhamnopyranosyl-(1 → 2)- α -L-arabinopyranoside showed inhibitory activity against Trichophyton rubrum with MIC80 value of 8 μg/mL, while oleanolic acid 3- O - α -L-arabinopyranosyl-(1 → 3)- α -L-rhamnopyranosyl-(1 → 2)- α -L-arabinopyranoside exhibited inhibitory activity against both Trichophyton rubrum and Candida albicans with MIC80 values of 8 μg/mL. Graphical abstract: Seventeen triterpenoid saponins, including 5 previously undescribed compounds, were isolated from the extract of Sapindus mukorossi Gaertn. pulps. Their structures were elucidated by HR-ESI-MS, spectroscopic techniques, and chemical methods. All the isolated compounds were evaluated for their antifungal activity against Candida albicans and Trichophyton rubrum . Some of the tested compounds showed moderate antifungal activity. Highlights: Five previously undescribed saponins were purified from Sapindus mukorossi. 16 μg/mL of one compound caused more than 99.9% C. albicans cell death within 4 h. Three compounds exhibited moderate anti T. rubrum activities.