Cover Feature: Rhodococcus erythropolis Oleate Hydratase: a New Member in the Oleate Hydratase Family Tree—Biochemical and Structural Studies (ChemCatChem 2/2018). Issue 2 (24th January 2018)

• Record Type: Journal Article
• Authors: Lorenzen, Jan; Driller, Ronja; Waldow, Ayk; Qoura, Farah; Loll, Bernhard; Brück, Thomas
• Is Part Of: ChemCatChem. Volume 10:Issue 2(2018)
• Page Start: 336
• Page End: 336
• Publication Date: 2018-01-24
• Subjects: oleate hydratase -- fatty acids -- hydration -- lyases -- protein structure; Catalysis -- Periodicals; 541.39505
• DOI: 10.1002/cctc.201800008
• Languages: English
• ISSNs: 1867-3880

Abstract

Abstract : The Cover Feature displays the crystal structure of the oleate hydratase OhyRe from Rhodococcus erythropolis, structurally and biochemically characterized for the first time, which catalyzes the hydration and dehydration of oleic acid. In their Full Paper, J. Lorenzen, R. Driller et al. elucidated the crystal structure of OhyRe, which revealed that the active form of OhyRe is a monomer, in contrast to other known oleate hydratase structures. Mutation of key residues resulted in decreased enzymatic activity, indicating a distinct reaction mechanism among the family members of hydratases. More information can be found in the Full Paper by J. Lorenzen, R. Driller et al. onpage 407 in Issue 2, 2018 (DOI:10.1002/cctc.201701350 ).