BRAF mutations might be more common than supposed in vulvar melanomas. Issue 2 (21st December 2017)

• Record Type: Journal Article
• Authors: Wylomanski, Sophie; Denis, Marc G.; Théoleyre, Sandrine; Bouquin, Réjane; Vallée, Audrey; Knol, Anne‐Chantal; Saint‐Jean, Mélanie; Peuvrel, Lucie; Dréno, Brigitte; Quéreux, Gaëlle
• Is Part Of: Experimental dermatology. Volume 27:Issue 2(2018)
• Page Start: 210
• Page End: 213
• Publication Date: 2017-12-21
• Subjects: female lower genital tract -- melanoma -- oncogenic mutations; Dermatology -- Periodicals; 616.5
• DOI: 10.1111/exd.13472
• Languages: English
• ISSNs: 0906-6705

Abstract

Abstract: Data on BRAF, NRAS and KIT mutations are scarce in patients with vulvo‐vaginal melanomas and are associated with important therapeutic issues. We investigated their prevalence in a cohort of patients with female lower genital tract melanomas between 2003 and 2017. Of the 22 patients, 5 (22.7%) harboured a BRAF mutation, which was much higher than the rate of 5% reported in the literature. One patient, who was tested negative on the primary melanoma, had a NRAS mutation in a cutaneous metastasis. Our data provide a rationale for prospective and repeated mutations testing in female lower genital tract melanomas.