Applications and Challenges for the Use of Phosphatidylethanol Testing in Liver Disease Patients (Mini Review). (28th December 2017)

• Record Type: Journal Article
• Authors: Nguyen, Van Long; Haber, Paul S.; Seth, Devanshi
• Is Part Of: Alcoholism. Volume 42:Number 2(2018)
• Page Start: 238
• Page End: 243
• Publication Date: 2017-12-28
• Subjects: Liver Disease -- Phosphatidylethanol -- Alcohol Consumption -- Applications -- Challenges; Alcoholism -- Periodicals; Alcoholism -- Periodicals; Alcoolisme; Electronic journals; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.861005
• DOI: 10.1111/acer.13558
• Languages: English
• ISSNs: 0145-6008

Abstract

Abstract : Phosphatidylethanol (PEth) is a direct nonoxidative metabolite of ethanol that may be measured in clinical samples as a marker for monitoring alcohol consumption. It has been used in a wide variety of clinical and nonclinical settings; however, its investigation in relation to liver disease has been limited. This study aims at providing a short review on the applications and challenges for the incorporation of PEth testing in identifying alcohol intake in this patient population. Abstract : Proposed hypothetical model of enhanced PEth formation in advanced liver disease. As liver disease progresses, the enzymatic activity of alcohol dehydrogenase and aldehyde dehydrogenase is decreased [1]. As a consequence oxidative metabolism of ethanol may be impaired yielding higher blood ethanol levels being shunted towards non‐oxidative PEth pathway via phospholipase D (PLD) [2]. PLD has a greater affinity for ethanol than its usual substrate phosphatidylcholine [3], suggesting the possibility of intrinsic PEth formation in erythrocytes [4].