Identification of pyrolysis products of the new psychoactive substance 2‐amino‐1‐(4‐bromo‐2, 5‐dimethoxyphenyl)ethanone hydrochloride (bk‐2C‐B) and its iodo analogue bk‐2C‐I. Issue 1 (31st May 2017)

• Record Type: Journal Article
• Authors: Texter, Kelly B.; Waymach, Rachel; Kavanagh, Pierce V.; O'Brien, John E.; Talbot, Brian; Brandt, Simon D.; Gardner, Elizabeth A.
• Is Part Of: Drug testing and analysis. Volume 10:Issue 1(2018)
• Page Start: 229
• Page End: 236
• Publication Date: 2017-05-31
• Subjects: pyrolysis -- phenethylamines -- new psychoactive substances -- profiling -- forensic chemistry; Drugs -- Analysis -- Periodicals; Drug testing -- Periodicals; Chemistry, Forensic -- Periodicals; 615.1901
• DOI: 10.1002/dta.2200
• Languages: English
• ISSNs: 1942-7603

Abstract

Abstract : 2‐Amino‐1‐(4‐bromo‐2, 5‐dimethoxyphenyl)ethanone hydrochloride ( bk ‐2C‐B) has recently emerged as a new psychoactive substance (NPS). It is most commonly consumed orally, although there are indications that it might also be ingested by inhalation or 'smoking'. Information about the stability of bk ‐2C‐B when exposed to heat is unavailable and the potential for pyrolytic degradation and formation of unknown substances available for inhalation prompted an investigation using a simulated 'meth pipe' scenario. Twelve products following pyrolysis of bk ‐2C‐B were detected and verified by organic synthesis of the corresponding standards. In addition, 2‐amino‐1‐(4‐iodo‐2, 5‐dimethoxyphenyl)ethanone hydrochloride ( bk ‐2C‐I) was characterized for the first time and subjected to pyrolysis as well. Similar products were formed, which indicated that the replacement of the bromo with the iodo substituent did not affect the pyrolysis pattern under the conditions used. Two additional products were detected in the bk ‐2C‐I pyrolates, namely 1‐(2, 5‐dimethoxyphenyl)‐ethanone and 1‐iodo‐4‐ethenyl‐5‐methoxyphenol. The potential ingestion of pyrolysis products with unknown toxicity adds an element of concern. Copyright © 2017 John Wiley & Sons, Ltd. Abstract : A study of the pyrolysis of two new beta keto analog of 2‐(4‐bromo‐2, 5‐dimethoxyphenyl) ethan‐1‐amine (2C–B), bk‐ 2C‐1. Products were formed by deamination, loss of the bk oxygen and halogenation.