Placenta‐on‐a‐Chip: Placental Drug Transport‐on‐a‐Chip: A Microengineered In Vitro Model of Transporter‐Mediated Drug Efflux in the Human Placental Barrier (Adv. Healthcare Mater. 2/2018). Issue 2 (24th January 2018)

• Record Type: Journal Article
• Authors: Blundell, Cassidy; Yi, Yoon‐Suk; Ma, Lin; Tess, Emily R.; Farrell, Megan J.; Georgescu, Andrei; Aleksunes, Lauren M.; Huh, Dongeun
• Is Part Of: Advanced healthcare materials. Volume 7:Issue 2(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-01-24
• Subjects: drug transport -- glyburide -- placenta‐on‐a‐chip; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201870008
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract : In article number1700786, Dongeun Huh and co‐workers present a micro‐engineered model of the human placental barrier for investigation of maternal–fetal drug transfer in pregnancy. The placenta‐on‐a‐chip system reconstitutes efflux transporter‐mediated transport of a test compound, demonstrating proof‐of‐principle for use as a screening platform for prediction of drug transport in pregnancy.