Polyketides with different post-modifications from desert endophytic fungus Paraphoma sp. Issue 8 (18th April 2018)

• Record Type: Journal Article
• Authors: Li, L. Y.; Sun, B. D.; Zhang, G. S.; Deng, H.; Wang, M. H.; Tan, X. M.; Zhang, X. Y.; Jia, H. M.; Zhang, H. W.; Zhang, T.; Zou, Z. M.; Ding, G.
• Is Part Of: Natural product research. Volume 32:Issue 8(2018)
• Page Start: 939
• Page End: 943
• Publication Date: 2018-04-18
• Subjects: Polyketides -- post-modifications -- desert endophytic fungus -- Paraphoma sp; Natural products -- Periodicals; Natural products -- Research -- Periodicals; Biological Factors -- Periodicals; Biological Products -- Periodicals; 547
• DOI: 10.1080/14786419.2017.1371166
• Languages: English
• ISSNs: 1478-6419

Abstract

Abstract: Three new polyketides 4, 6, 8-trihydroxy-5-methyl-3, 4-dihydronaphthalen-1(2 H )-one (1 ), 5, 7-dihydroxy-3-(1-hydroxyethyl)-3, 4-dimethylisobenzofuran-1(3 H )-one (2 ) and 1-(4-hydroxy-6-methoxy-1, 7-dimethyl-3-oxo-1, 3-dihydroisobenzofuran-1-yl) ethyl acetate (3 ) together with seven known analogues (4 –10 ) were isolated from desert endophytic fungus Paraphoma sp. The structures of these compounds were elucidated by analysis of NMR data. The absolute configuration of (1 –3 ) was established on the basis of CD experiments. The possible biosynthetic pathway of compounds (1 –10 ) was suggested, which implied that these secondary metabolites might be originated from polyketide biosynthesis with different post-modification reactions. Compounds2, and5 –8 were evaluated for bioactivities against plant pathogen A . solani, whereas none of them displayed any biological effects. In addition, compounds1, 2 and5 –10 were also tested for cytotoxic activities against three human cancer cell lines (HepG2 cells, MCF-7 cells and Hela cells) without biological effects. Abstract :