Palladium-catalyzed three-component reaction for the synthesis of 3, 3-disubstituted allylic alcohols with regio- and stereoselectivity. (5th January 2018)

• Record Type: Journal Article
• Authors: Hu, Gang; Wang, Jingtao; Li, Zefei; Liu, Yajing; Gong, Ping
• Is Part Of: New journal of chemistry. Volume 42:Number 3(2018)
• Page Start: 1736
• Page End: 1739
• Publication Date: 2018-01-05
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c7nj04342b
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : A novel three-component assembly of allenic alcohols, aryl iodides and 1, 3-dicarbonyl compounds into 3, 3-disubstituted allylic alcohols was promoted in the presence of a palladium source. Abstract : A novel three-component assembly of allenic alcohols, aryl iodides and 1, 3-dicarbonyl compounds into 3, 3-disubstituted allylic alcohols was promoted in the presence of a palladium source. A plausible mechanism through Pd 0 catalysis was established to explain the regio- and stereoselectivity. Various aryl iodides and functionalized dicarbonyls were well-tolerated to afford products in good to moderate yields.