Mitochondria-targeted ratiometric fluorescent detection of hydrazine with a fast response time. (15th January 2018)

• Record Type: Journal Article
• Authors: Ban, Yanan; Wang, Ruihui; Li, Yang; An, Zhen; Yu, Mingming; Fang, Chenjie; Wei, Liuhe; Li, Zhanxian
• Is Part Of: New journal of chemistry. Volume 42:Number 3(2018)
• Page Start: 2030
• Page End: 2035
• Publication Date: 2018-01-15
• Subjects: Chemistry -- Periodicals; Chimie -- Périodiques; 540
• DOI: 10.1039/c7nj04212d
• Languages: English
• ISSNs: 1144-0546

Abstract

Abstract : A fluorescent hydrazine-probe was synthesized, which exhibited high sensitivity, excellent selectivity and anti-interference ability. Abstract : A ratiometric fluorescent probe1 was synthesized, which exhibited high sensitivity and excellent selectivity for hydrazine recognition. Probe1 can quantitatively detect hydrazine in the concentration range from 30 to 180 μM with a LOD of 2.1 μM. Furthermore, it displayed excellent selectivity, anti-interference over many nucleophilic species, biological species, metal ions and anions, and a fast response time (4 min). Due to its ability to target mitochondria, the response of hydrazine to this probe in a living cell was successfully tracked in a ratiometric manner via fluorescence imaging.