Both Carvedilol and Nebivolol May Improve Platelet Function and Prothrombotic State in Patients With Nonischemic Heart Failure. (July 2014)

• Record Type: Journal Article
• Authors: Karabacak, Mustafa; Dogan, Abdullah; Aksoy, Fatih; Ozaydin, Mehmet; Erdogan, Dogan; Karabacak, Pinar
• Is Part Of: Angiology. Volume 65:Number 6(2014)
• Page Start: 533
• Page End: 537
• Publication Date: 2014-07
• Subjects: carvedilol -- nebivolol -- heart failure -- mean platelet volume -- d-dimer -- fibrinogen; Blood-vessels -- Diseases -- Periodicals; Cardiovascular system -- Diseases -- Periodicals; 616.13005
• DOI: 10.1177/0003319713489340
• Languages: English
• ISSNs: 0003-3197

Abstract

It is unclear whether carvedilol and nebivolol will produce different effects on platelet function and prothrombotic state in heart failure (HF). Thus, we compared their effects on these functions in patients with nonischemic HF. We included 61 patients with symptomatic nonischemic HF having ejection fraction ≤40%. The patients were randomized to carvedilol (n = 31) or nebivolol (n = 30). Analyses were made at baseline, 3, and 6 months. At 6 months, mean platelet volume (MPV) was significantly lowered by both carvedilol and nebivolol therapy. However, MPV tended to be lower in the carvedilol group (7.7 ± 1.0 vs 8.0 ± 0.7 fL, P = .05). Fibrinogen andd -dimer levels were significantly decreased in but comparable in both the groups. Carvedilol and nebivolol have similar beneficial effects on platelet function and prothrombotic state in patients with nonischemic HF.