Eugenol triggers CD11b+Gr1+ myeloid-derived suppressor cell apoptosis via endogenous apoptosis pathway. Issue 7 (19th January 2018)

• Record Type: Journal Article
• Authors: Ding, Ying; Yang, Zecheng; Zhang, Wensheng; Xu, Yuwei; Wang, Yuanyuan; Hu, Minghua; Ma, Fangli; Long, Hanan; Tao, Ning; Qin, Zhihai
• Is Part Of: RSC advances. Volume 8:Issue 7(2018)
• Page Start: 3833
• Page End: 3838
• Publication Date: 2018-01-19
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c7ra13499a
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : To study the effect and underlying molecular mechanism of eugenol on CD11b + Gr1 + myeloid-derived suppressor cells (MDSCs). Abstract : To study the effect and underlying molecular mechanism of eugenol on CD11b + Gr1 + myeloid-derived suppressor cells (MDSCs). The effect of eugenol on the inhibition of immortalized MDSC cell line MSC-2 and murine peritoneal macrophages was detected by MTT. Flow cytometry was used to detect the pro-apoptosis effect of eugenol on MDSCs. The expression levels of apoptosis-related proteins were detected by western blot. Eugenol has a selective inhibitory effect on MDSCs in a dose-dependent manner, which activates an endogenous apoptosis pathway, leading to apoptosis. Eugenol promotes the apoptosis of MDSCs via the intrinsic pathway.