Strigolactones: a plant phytohormone as novel anti-inflammatory agents. Issue 1 (22nd December 2017)

• Record Type: Journal Article
• Authors: Zheng, Jun-Xia; Han, Yu-Shui; Wang, Jin-Cai; Yang, Hui; Kong, Hao; Liu, Kang-Jia; Chen, Si-Yu; Chen, Yi-Rui; Chang, Yi-Qun; Chen, Wei-Min; Guo, Jia-Liang; Sun, Ping-Hua
• Is Part Of: MedChemComm. Volume 9:Issue 1(2018)
• Page Start: 181
• Page End: 188
• Publication Date: 2017-12-22
• Subjects: Pharmaceutical chemistry -- Periodicals; 615.19
• DOI: 10.1039/c7md00461c
• Languages: English
• ISSNs: 2040-2503

Abstract

Abstract : Strigolactones (SLs), a representative SL, GR24 and its reductive products of D-ring were synthesized and their anti-inflammatory activities were fully evaluated on both in vitro and in vivo models. Abstract : Strigolactones (SLs) are a novel class of plant hormones with enormous potential for the prevention and treatment of inflammation. To further investigate the anti-inflammatory activities of SLs, a representative SL, GR24, and the reductive products of its D-ring were synthesized and their anti-inflammatory activities were fully evaluated on both in vitro and in vivo models. Among these compounds, the two most active optical isomers (2a and6a ) demonstrated strong inhibitory activity on the release of inflammatory cytokines, including nitric oxide (NO), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) by blocking the nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways; they also greatly inhibited the migration of neutrophils and macrophages in fluorescent protein labeled zebrafish larvae. These results identified the promising anti-inflammatory effects of SLs, and suggested that both the absolute configuration of SL and the α, β-unsaturated D-ring structure are essential for the observed anti-inflammatory activity.