PARP-1 involvement in neurodegeneration: A focus on Alzheimer's and Parkinson's diseases. (March 2015)

• Record Type: Journal Article
• Authors: Martire, Sara; Mosca, Luciana; d'Erme, Maria
• Is Part Of: Mechanisms of ageing and development. Volume 146/147/148(2015)
• Page Start: 53
• Page End: 64
• Publication Date: 2015-03
• Subjects: Alzheimer's disease -- Parkinson's disease -- Poly(ADP-ribose)polymerase -- Mitochondria; Aging -- Periodicals; Developmental biology -- Periodicals; Aging -- Periodicals; Developmental Biology -- Periodicals; Vieillissement -- Périodiques; Biologie du développement -- Périodiques; Aging; Developmental biology; Periodicals; 612.67
• DOI: 10.1016/j.mad.2015.04.001
• Languages: English
• ISSNs: 0047-6374

Abstract

Graphical abstract: Abstract: DNA damage is the prime activator of the enzyme poly(ADP-ribose)polymerase1 (PARP-1) whose overactivation has been proven to be associated with the pathogenesis of numerous central nervous system disorders, such as ischemia, neuroinflammation, and neurodegenerative diseases. Under oxidative stress conditions PARP-1 activity increases, leading to an accumulation of ADP-ribose polymers and NAD + depletion, that induces energy crisis and finally cell death. This review aims to explain the contribution of PARP-1 in neurodegenerative diseases, focusing on Alzheimer's and Parkinson's disease, to stimulate further studies on this issue and thereby engage a new perspective regarding the design of possible therapeutic agents or the identification of biomarkers.