Profile of GenMark's ePlex® blood culture identification fungal pathogen panel. (1st February 2018)

• Record Type: Journal Article
• Authors: Maubon, Danièle; Dard, Céline; Garnaud, Cécile; Cornet, Muriel
• Is Part Of: Expert review of molecular diagnostics. Volume 18:Number 2(2018)
• Page Start: 119
• Page End: 132
• Publication Date: 2018-02-01
• Subjects: Fungemia -- candidemia -- invasive fungal infection -- diagnosis -- molecular diagnostic -- blood culture -- PCR -- antifungal stewardship; Molecular diagnosis -- Periodicals; 616.0758205
• DOI: 10.1080/14737159.2018.1420476
• Languages: English
• ISSNs: 1473-7159

Abstract

ABSTRACT: Introduction : Fungemia presents high morbi-mortality and thus rapid microbiological diagnosis may contribute to appropriate patient management. In the last decade, kits based on molecular technologies have become available and health care institutes are increasingly facing critical investment choices. Although all these tools aim to achieve rapid fungal detection and species identification, they display different inherent characteristics. Areas covered : Considering technologies allowing detection and identification of fungal species in a sepsis context, the market proposes either tests on positive blood culture or tests on patient's whole blood. In this review, the authors describe and compare the ePlex® Blood Culture Identification Fungal Pathogen (BCID-FP) test, a fully automated one-step single-use cartridge assay that has been designed to detect identify frequent or rare but emerging, fungal species, from positive blood culture. A comparison with the competing kits is provided. Expert commentaries : The ePlex BCID-FP test provides a diversified and rather relevant panel. Its easy-to-use cartridges allow flexible use around the clock. Nevertheless, prospective clinical studies assessing the time-to-result benefit on antifungal stewardship and on hospital length of stay are not available yet. New tools aim to benefit clinicians and patients, but they should be accompanied by supervision of result interpretation and adaptation of antifungal stewardship.