DABCO-catalyzed silver-promoted direct thiolation of pyrazolones with diaryl disulfides. Issue 3 (21st December 2017)

• Record Type: Journal Article
• Authors: Thupyai, Akkharaphong; Pimpasri, Chaleena; Yotphan, Sirilata
• Is Part Of: Organic & biomolecular chemistry. Volume 16:Issue 3(2017)
• Page Start: 424
• Page End: 432
• Publication Date: 2017-12-21
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c7ob02860a
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Efficient direct thiolation of N -substituted pyrazolones with diaryl disulfides was developed using a combination of DABCO and AgOAc to assist C–S bond formation. Abstract : A highly efficient protocol for a direct thiolation of N -substituted pyrazolones with diaryl disulfides is described. Using a combination of DABCO and silver(i ) acetate, the C–S bond formation proceeds smoothly at room temperature under mild and easy to handle conditions. This synthetic strategy offers a convenient and direct modification of antipyrine and other pyrazolone substrates, giving a series of aryl sulfide-substituted pyrazolone products in moderate to excellent yields.