Probing molecular forces in multi-component physiological membranes. Issue 4 (27th November 2017)

• Record Type: Journal Article
• Authors: Ray, Arjun; Gräter, Frauke; Thukral, Lipi
• Is Part Of: Physical chemistry chemical physics. Volume 20:Issue 4(2017)
• Page Start: 2155
• Page End: 2161
• Publication Date: 2017-11-27
• Subjects: Chemistry, Physical and theoretical -- Periodicals; 541.3
• DOI: 10.1039/c7cp05981g
• Languages: English
• ISSNs: 1463-9076

Abstract

Abstract : By combining MD simulations and the newly developed Lipid-Force Distribution Analysis (L-FDA), we explore force transmission in complex multi-component membrane models mimicking eukaryotic organelles. We found that the chemical-moiety based segmentation at membrane interfaces revealed a distinctive distribution of bonded and non-bonded forces in diverse membrane environment. Abstract : Biological membranes are remarkably heterogeneous, composed of diverse lipid mixtures with distinct chemical structure and composition. By combining molecular dynamics simulations and the newly developed Lipid-Force Distribution Analysis (L-FDA), we explore force transmission in complex multi-component membrane models mimicking eukaryotic organelles. We found that the chemical-moiety based segmentation at membrane interfaces revealed a distinctive distribution of bonded and non-bonded forces in diverse membrane environment. Our molecular stress analysis could have far-reaching implications in describing the relationship between membrane mechanical properties and functional states of chemically distinct lipids.