Mono- and dioxido-vanadium(V) complexes of a tridentate ONO Schiff base ligand: Synthesis, spectral characterization, X-ray crystal structure, and anticancer activity. (17th June 2015)

• Record Type: Journal Article
• Authors: Ebrahimipour, S. Yousef; Sheikhshoaie, Iran; Kautz, Anna Christin; Ameri, Mojgan; Pasban-Aliabadi, Hamzeh; Amiri Rudbari, Hadi; Bruno, Giuseppe; Janiak, Christoph
• Is Part Of: Polyhedron. Volume 93(2015)
• Page Start: 99
• Page End: 105
• Publication Date: 2015-06-17
• Subjects: Oxido-vanadium(V) complex -- ONO Schiff base ligand -- Crystal structure -- Anticancer activity -- Cell viability; Chemistry, Inorganic -- Periodicals; Chimie inorganique -- Périodiques; Organometaalverbindingen; Anorganische chemie; 546.05
• DOI: 10.1016/j.poly.2015.03.037
• Languages: English
• ISSNs: 0277-5387

Abstract

Graphical abstract: Three oxido-vanadium(V) complexes, [VO2 (L)][NH(Et)3 ] (1 ), [VO(L)(PrO)] (2 ) and [VO(L)(BuO)] (3 ), have been synthesized and characterized using physicochemical and spectroscopic methods. Furthermore, the anticancer activity of these compounds was investigated against MCF-7 (breast cancer) cells. Abstract: Three oxido-vanadium(V) complexes, [VO2 (L)][NH(Et)3 ] (1 ), [VO(L)(PrO)] (2 ) and [VO(L)(BuO)] (3 ), containing deprotonated form of the tridentate Schiff base ligand 1-(((5-chloro-2-oxidophenyl)imino)methyl)naphthalen-2-olate [L 2− ] have been synthesized and characterized using elemental analysis, molar conductivity, FTIR, 1 H NMR analysis, and electronic spectroscopy. The structures of the free H2 L ligand and all the complexes were determined by single crystal X-ray diffraction. According to the spectroscopic and structural data, H2 L exists in the solid state in a zwitterionic form. In all the complexes, the V(V) center is coordinated by the ONO donor set of the L 2− ligand, one or two oxido groups and in the case of2 and3 by one alkoxide group (PrO − for2 and BuO − for3 ) in a distorted square pyramidal geometry. The anticancer activities of the title complexes have been also investigated against MCF-7 (breast cancer) cells and compared with that of VO(acac)2 . According to the obtained results, all the complexes possess higher anticancer activity than VO(acac)2 .