Relationship of Vitamin D, HIV, HIV Treatment, and Lipid Levels in the Women's Interagency HIV Study of HIV-Infected and Uninfected Women in the United States. (May 2014)

• Record Type: Journal Article
• Authors: Schwartz, Janice B.; Moore, Kelly L.; Yin, Michael; Sharma, Anjali; Merenstein, Dan; Islam, Talat; Golub, Elizabeth T.; Tien, Phyllis C.; Adeyemi, Oluwatoyin M.
• Is Part Of: Journal of the International Association of Providers of AIDS Care. Volume 13:Number 3(2014:May/Jun.)
• Page Start: 250
• Page End: 259
• Publication Date: 2014-05
• Subjects: vitamin D -- lipids -- HIV infected -- HIV uninfected -- 25-OH vitamin D -- cholesterol -- LDL cholesterol -- triglycerides -- lipids -- WIHS; AIDS (Disease) -- Periodicals; 616.9792
• DOI: 10.1177/2325957413506748
• Languages: English
• ISSNs: 2325-9574

Abstract

Relationships between vitamin D, lipids, HIV infection, and HIV treatment (±antiretroviral therapy [ART]) were investigated with Women's Interagency HIV Study data (n = 1758 middle-aged women) using multivariable regression. Sixty-three percent of women had vitamin D deficiency. Median 25-hydroxyvitamin D (25-OH vitamin D) was highest in HIV-infected + ART-treated women (17 ng/mL; P < .001) and was the same in HIV-uninfected or HIV-infected women without ART (14 ng/mL). Vitamin D levels were lower if efavirenz (EFV) was included in ART (15 versus 19 ng/mL; P < .001). The most common lipid abnormality was high triglycerides (≥200 mg/dL) in HIV-infected + ART-treated women (13% versus 7% of HIV-infected without ART and 5% of HIV-uninfected; P < .001), with a positive relationship between 25-OH vitamin D and triglycerides (95% confidence interval 0.32-1.69; P < .01). No relationships between 25-OH vitamin D and cholesterol were detected. Vitamin D deficiency is common irrespective of HIV status but influenced by HIV treatment. Similarly, vitamin D levels were positively related to triglycerides only in ART-treated HIV-infected women and unrelated to cholesterol.