Carbon Dioxide Laser Versus Stapler-Assisted Endoscopic Zenker's Diverticulotomy: A Systematic Review and Meta-Analysis. (May 2014) - Parker, Noah P.
To evaluate outcomes following endoscopic management of Zenker's diverticula using a carbon dioxide laser (CO2 ) or stapler-assisted technique, a systematic review and meta-analysis were conducted. Seven retrospective, uncontrolled case series including 391 procedures met selection criteria. No higher quality studies were identified. Outcomes favoring the stapler technique included a shorter duration of nil per os (NPO) status (2 studies), length of hospitalization (LOH, 2 studies), and fewer postoperative fevers and abnormal chest x-rays (1 study). Outcomes favoring the CO2 technique included greater improvement in postoperative dysphagia and regurgitation scores (2 studies) and a lower revision rate (1 study). Meta-analysis demonstrated increased nondental complications in the CO2 group (odds ratio 3.81; 95% confidence interval, 1.37-10.59; P = .01) but no difference in duration of NPO ( P = .06), LOH ( P = .07), overall complications ( P = .08), dental complications ( P = .57), major complications ( P = .38), or revision surgery ( P = .82). Implications are limited by the quality of studies identified.