Synthesis and in vitro cytotoxicity of novel dinuclear platinum(II) complexes containing a chiral tetradentate ligand. Issue 22 (17th November 2017)

• Record Type: Journal Article
• Authors: Bai, Linkui; Gao, Chuanzhu; Cai, Linxiang; Liu, Qinghua; Qian, Yunxu; Yang, Bo
• Is Part Of: Journal of coordination chemistry. Volume 70:Issue 22(2017)
• Page Start: 3759
• Page End: 3768
• Publication Date: 2017-11-17
• Subjects: Dinuclear platinum(II) complexes -- trans-1R, 2R-Diaminocyclohexane -- Cytotoxicity -- DNA Insertion group; Coordination compounds -- Periodicals; 541.2242
• DOI: 10.1080/00958972.2017.1398822
• Languages: English
• ISSNs: 0095-8972

Abstract

Abstract: A series of novel dinuclear platinum(II) complexes with a chiral tetradentate ligand, (1 R, 1′ R, 2 R, 2′ R )- N 1, N 1 ′-(1, 2-phenylenebis(methylene))dicyclohexane-1, 2-diamine (HL), and mono -carboxylic acid derivatives as ligands have been designed, synthesized, and characterized. In vitro cytotoxicity evaluation of synthesized complexes against human HepG-2, A549, HCT-116, and MCF-7 cancer cell lines has been conducted by MTT assays. All compounds showed antitumor activity to HepG-2 and HCT-116 cell lines. CompoundL2 exhibited better cytotoxicity than that of carboplatin against HepG-2 and A549 cell lines and also showed comparable activity against HCT-116 cell line. Abstract :