A multifunctional porous scaffold with capacities of minimally invasive implantation, self-fitting and drug delivery. (October 2016)

• Record Type: Journal Article
• Authors: Di, Shubin; Liu, Xian; Liu, Dian; Gong, Tao; Lu, Liuxuan; Zhou, Shaobing
• Is Part Of: Materials today chemistry. Volume 1/2(2016)
• Page Start: 52
• Page End: 62
• Publication Date: 2016-10
• Subjects: Shape memory polymer -- Self-fitting -- Drug delivery -- Bioactive -- Tissue engineering; Chemistry -- Periodicals; Materials -- Research -- Periodicals; Materials science -- Periodicals; Chemistry; Materials -- Research; Electronic journals; Periodicals; 660.282
• DOI: 10.1016/j.mtchem.2016.11.004
• Languages: English
• ISSNs: 2468-5194

Abstract

Abstract: Maxillary sinus floor elevation is of frequent occurrence and extremely important for dental implantation. However, how to conveniently implant a synthetic scaffold in the irregular bony cavity of maxillary sinus and simultaneously prompt new bone regeneration is a great challenge in lifting the maxillary sinus floor. Here, we develop a bioactive self-fitting polymer porous scaffold via one-step creation of interconnected pores with controllable size and loading with a bone morphogenetic protein-2 (BMP-2) therapeutic agent inside these pores for the first time. This scaffold can be compressed like a sponge for minimally invasive surgery and return to its original porous structure in response to a temperature of 41 °C for self-fitting into the irregular cavity of a maxillary sinus. Moreover, the loaded BMP-2 possesses a great capacity to accelerate new bone regeneration. Highlights: A bioactive self-fitting polymer porous scaffold is developed via one-step creation of interconnected pores. This scaffold can be compressed like a sponge for minimally invasive surgery. The loaded BMP-2 possesses a great capacity to accelerate new bone regeneration.