How genomic studies have improved our understanding of the mechanisms of transcriptional regulation by NR5A nuclear receptors. (15th June 2015)

• Record Type: Journal Article
• Authors: Ruggiero, Carmen; Doghman, Mabrouka; Lalli, Enzo
• Is Part Of: Molecular and cellular endocrinology. Volume 408(2015)
• Page Start: 138
• Page End: 144
• Publication Date: 2015-06-15
• Subjects: SF-1 steroidogenic factor-1 -- LRH-1 liver receptor homolog-1 -- iPSC induced pluripotent stem cells -- TSS transcription start site -- VMH ventro-medial hypothalamic nucleus; Adrenal cortex -- Endocrine cancers -- Transcription factors -- Nuclear receptors; Endocrinology -- Periodicals; Molecular biology -- Periodicals; Cytology -- Periodicals; Endocrinology -- Periodicals; Hormones -- Periodicals; Endocrinologie -- Périodiques; Cytology; Endocrinology; Molecular biology; Periodicals; 573.4
• DOI: 10.1016/j.mce.2014.10.022
• Languages: English
• ISSNs: 0303-7207

Abstract

Highlights: SF-1 and LRH-1 are nuclear receptors that belong to the NR5A subclass. They bind as monomers to nuclear receptor half-sites. They have a critical role in development, physiology and are also implicated in endocrine cancers. Recent genome-wide studies have shed light on the mechanisms of transcriptional regulation by NR5A nuclear receptors. Abstract: SF-1 and LRH-1 are transcription factors that belong to the NR5A family of nuclear receptors that both have an essential role during development. Recent studies at the genome-wide scale have enabled the characterization of the cistrome and transcriptome regulated by SF-1 and LRH-1 in different cell lines and tissues. Those studies have allowed us to make a significant leap forward in our understanding of the mechanisms of transcriptional regulation of NR5A nuclear receptors in stem cells and cancer.