Growth axis maturation is linked to nutrition, growth and developmental rate. (15th August 2015)
- Record Type:
- Journal Article
- Title:
- Growth axis maturation is linked to nutrition, growth and developmental rate. (15th August 2015)
- Main Title:
- Growth axis maturation is linked to nutrition, growth and developmental rate
- Authors:
- Hetz, Jennifer A.
Menzies, Brandon R.
Shaw, Geoffrey
Rao, Alexandra
Clarke, Iain J.
Renfree, Marilyn B. - Abstract:
- Highlights: Marsupials give birth to altricial young developmentally similar to fetal eutherians. Nutritional intake of pouch young can be easily manipulated. Enhanced nutrition of the pouch young increases growth factor production in the liver and growth. Accelerated growth results in earlier growth axis maturation. Graphical Abstract: Abstract: Maturation of the mammalian growth axis is thought to be linked to the transition from fetal to post-natal life at birth. However, in an altricial marsupial, the tammar wallaby ( Macropus eugenii ), this process occurs many months after birth but at a time when the young is at a similar developmental stage to that of neonatal eutherian mammals. Here we manipulate growth rates and demonstrate in slow, normal and fast growing tammar young that nutrition and growth rate affect the time of maturation of the growth axis. Maturation of GH/IGF-I axis components occurred earlier in fast growing young, which had significantly increased hepatic GHR, IGF1 and IGFALS expression, plasma IGF-I concentrations, and significantly decreased plasma GH concentrations compared to age-matched normal young. These data support the hypothesis that the time of maturation of the growth axis depends on the growth rate and maturity of the young, which can be accelerated by changing their nutritional status.
- Is Part Of:
- Molecular and cellular endocrinology. Volume 411(2015)
- Journal:
- Molecular and cellular endocrinology
- Issue:
- Volume 411(2015)
- Issue Display:
- Volume 411, Issue 2015 (2015)
- Year:
- 2015
- Volume:
- 411
- Issue:
- 2015
- Issue Sort Value:
- 2015-0411-2015-0000
- Page Start:
- 38
- Page End:
- 48
- Publication Date:
- 2015-08-15
- Subjects:
- Marsupial -- Endocrinology -- GH -- IGF-I -- IGF-II -- GHR
Endocrinology -- Periodicals
Molecular biology -- Periodicals
Cytology -- Periodicals
Endocrinology -- Periodicals
Hormones -- Periodicals
Endocrinologie -- Périodiques
Cytology
Endocrinology
Molecular biology
Periodicals
573.4 - Journal URLs:
- http://www.sciencedirect.com/science/journal/03037207 ↗
http://www.elsevier.com/journals ↗ - DOI:
- 10.1016/j.mce.2015.04.009 ↗
- Languages:
- English
- ISSNs:
- 0303-7207
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 5900.760000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 5698.xml