Milk lipid composition is modified by perinatal exposure to bisphenol A. (15th August 2015)

• Record Type: Journal Article
• Authors: Altamirano, Gabriela A.; Muñoz-de-Toro, Mónica; Luque, Enrique H.; Gómez, Ayelén L.; Delconte, Melisa B.; Kass, Laura
• Is Part Of: Molecular and cellular endocrinology. Volume 411(2015)
• Page Start: 258
• Page End: 267
• Publication Date: 2015-08-15
• Subjects: Bisphenol A -- Mammary gland differentiation -- Milk fat globules -- Milk fatty acid profile -- Lactation; ACCα acetyl CoA carboxylase -- ADPH adipophilin -- AA arachidonic acid -- BPA bisphenol A -- BTN butyrophilin -- CLD cytoplasmic lipid droplet -- EDCs endocrine-disrupting chemicals -- F0 dams directly exposed to xenoestrogens -- F1 F0 offspring -- F2 F1 offspring -- FA fatty acid -- FAMEs fatty acid methyl esters -- FAS fatty acid synthase -- GD gestation day -- LD lactation day -- LA linoleic acid -- LPL lipoprotein lipase -- MFG milk fat globule -- MUFA monosaturated fatty acid -- ORO Oil Red O -- PLIN perilipin -- PPARγ peroxisome proliferator-activated receptor gamma -- PUFA polyunsaturated fatty acid -- SCD2 stearoyl-CoA desaturase -- SFA saturated fatty acid -- SREBP1 sterol regulatory element-binding protein 1 -- TG triglyceride -- XOR xanthine oxide reductase; Endocrinology -- Periodicals; Molecular biology -- Periodicals; Cytology -- Periodicals; Endocrinology -- Periodicals; Hormones -- Periodicals; Endocrinologie -- Périodiques; Cytology; Endocrinology; Molecular biology; Periodicals; 573.4
• DOI: 10.1016/j.mce.2015.05.007
• Languages: English
• ISSNs: 0303-7207

Abstract

Highlights: BPA exposure delays mammary gland alveolar maturation during secretory activation. The synthesis and/or secretion of milk fat globules are modified in BPA-exposed dams. Milk lipid content and fatty acid composition are affected by BPA exposure. Abstract: To evaluate whether bisphenol A (BPA) modifies the synthesis, composition and/or profile of fatty acids (FAs) in the mammary glands of perinatally exposed animals, pregnant rats were orally exposed to 0, 0.6 or 52 µg BPA/kg/day from gestation day (GD) 9 until weaning. F1 females were bred, and on GD21, lactation day 2 (LD2) and LD10, mammary glands were obtained. On LD10, milk samples were collected, and FA profiles and lipid compositions were established. On GD21 and LD2, BPA exposure delayed mammary alveolar maturation and modified the synthesis of milk fat globules. On LD10, mammary gland histo-architecture was restored; however, the milk of BPA-exposed F1 dams had a FA profile and lipid concentration different from those of the control milk. Furthermore, the body weight gain of BPA52 F2 pups was increased compared with control animals. Thus, perinatal exposure to BPA modifies milk quality, compromising the normal growth of offspring.