Cryptococcus neoformans meningitis with negative cryptococcal antigen: Evaluation of a new immunochromatographic detection assay. (March 2015)

• Record Type: Journal Article
• Authors: Opota, O.; Desgraz, B.; Kenfak, A.; Jaton, K.; Cavassini, M.; Greub, G.; Prod'hom, G.; Giulieri, S.
• Is Part Of: New microbes and new infections. Volume 4(2015)
• Page Start: 1
• Page End: 4
• Publication Date: 2015-03
• Subjects: Cryptococcus neoformans -- HIV -- immunochromatography -- meningitis -- Antigen test; Medical microbiology -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; Microbiology -- Periodicals; Communicable Diseases -- Periodicals; Infection -- Periodicals; 616.9041
• DOI: 10.1016/j.nmni.2014.12.003
• Languages: English
• ISSNs: 2052-2975

Abstract

Abstract: Detection of cryptococcal antigen in serum or cerebrospinal fluid allows cryptococcal meningitis diagnosis within few hours with >90% sensitivity. In an HIV-positive patient with Cryptococcus neoformans meningitis, initial antigen detection by immunoagglutination was negative. We thus evaluated a new immunochromatographic detection assay that exhibited a higher sensitivity.