The bacterial pangenome as a new tool for analysing pathogenic bacteria. (September 2015)

• Record Type: Journal Article
• Authors: Rouli, L.; Merhej, V.; Fournier, P.-E.; Raoult, D.
• Is Part Of: New microbes and new infections. Volume 7(2015)
• Page Start: 72
• Page End: 85
• Publication Date: 2015-09
• Subjects: Bacteria -- bioinformatics tools -- comparative genomics -- pangenome -- pathogenic species; Medical microbiology -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; Microbiology -- Periodicals; Communicable Diseases -- Periodicals; Infection -- Periodicals; 616.9041
• DOI: 10.1016/j.nmni.2015.06.005
• Languages: English
• ISSNs: 2052-2975

Abstract

Abstract: The bacterial pangenome was introduced in 2005 and, in recent years, has been the subject of many studies. Thanks to progress in next-generation sequencing methods, the pangenome can be divided into two parts, the core (common to the studied strains) and the accessory genome, offering a large panel of uses. In this review, we have presented the analysis methods, the pangenome composition and its application as a study of lifestyle. We have also shown that the pangenome may be used as a new tool for redefining the pathogenic species. We applied this to the Escherichia coli and Shigella species, which have been a subject of controversy regarding their taxonomic and pathogenic position. Highlights: Pangenome is a new way of studying pathogenic bacteria. Pangenome can be used as a taxonomic tool. This review describes pangenome in the world of pathogenic bacteria.