Decontamination of rat and human skin experimentally contaminated with 99mTc, 201Tl and 131I radionuclides using "Dermadecon" – a skin decontamination kit: an efficacy study. (2nd January 2018)

• Record Type: Journal Article
• Authors: Nishad, Dhruv Kumar; Bhalla, Supriya; Khanna, Kushagra; Sharma, Braj Gaurav; Rawat, Harish Singh; Mittal, Gaurav; Bhatnagar, Aseem
• Is Part Of: Cutaneous and ocular toxicology. Volume 37:Number 1(2018)
• Page Start: 1
• Page End: 8
• Publication Date: 2018-01-02
• Subjects: 99mTcO4− -- 201TlCl -- 131I -- decontamination efficiency -- dermadecon -- scintigraphy; Dermatotoxicology -- Periodicals; Ocular toxicology -- Periodicals; Ocular pharmacology -- Periodicals; Dermatopharmacology -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1080/15569527.2017.1315127
• Languages: English
• ISSNs: 1556-9527

Abstract

Abstract: Radioactive skin contamination is one of the most likely risks which occurs after accidental or occupational radiological accidents apart from internal contamination. In such cases where the radioactive contamination has occurred, the person who is contaminated should be decontaminated as early as possible to reduce the damaging health effects of radiation. In the present study, the decontamination efficiency of a developed skin decontamination kit "dermadecon" has been evaluated in animal models and human subjects using gamma scintigraphy. Decontamination efficiency (percentage of the radioactive contaminant removed) was calculated for each radioactive isotope of the study and compared with control where general washing procedure was followed using liquid and soap. The effectiveness of the kit was calculated in animal model with respect to 99m Tc-sodium-pertechnetate ( 99m TcO 4− ), 201 TlCl and 131 I and was found 92.84 ± 4.9%, 91.18 ± 3.23% and 94.67 ± 2.92%, respectively. Whereas, in case of human skin, the decontamination efficiency for 99m TcO 4− was observed to be 95.00 ± 3.21%. On the basis of findings from the study, it can be concluded that the decontamination agents of the used skin decontamination kit are effective for removal of localized radioactive contaminants from skin, as compared with normal decontamination using soap and water.