Concentric photothermal coagulation with basket‐integrated optical device for treatment of tracheal stenosis. Issue 1 (5th October 2017)

• Record Type: Journal Article
• Authors: Tran, Van N.; Lee, Hyoung Shin; Truong, Van G.; Rhee, Yun‐Hee; Kang, Hyun Wook
• Is Part Of: Journal of biophotonics. Volume 11:Issue 1(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2017-10-05
• Subjects: basket -- circumferential coagulation -- optical diffuser -- tracheal stenosis; Photonics -- Periodicals; Optical materials -- Periodicals; Optics -- Periodicals; Medical instruments and apparatus -- Periodicals; 621.3605
• DOI: 10.1002/jbio.201700073
• Languages: English
• ISSNs: 1864-063X

Abstract

Abstract : A basket‐integrated optical device is developed to consistently treat tubular tissue by centering an optical diffuser in the lumen. Four nitinol arms in conjunction with the optical diffusing applicator are deployed to induce homogeneous circumferential light emission and concentric photothermal coagulation on tracheal tissue. A 1470‐nm laser light is employed for the tissue testing at various irradiation conditions and evaluated in terms of thermal gradient and temperature evolution. Preliminary experiments on liver tissue demonstrate the concentric development of the radial thermal coagulation in the tissue (eccentric ratio = ~5.5%). The interstitial tissue temperature increases with the total amount of energy delivery (around 65°C). Ex vivo trachea testing yields up to 16.5% tissue shrinkage due to dehydration as well as uniform ablation of the cilia and goblet cells in a mucosa layer under 7‐W irradiation for 10 s. The proposed optical device may be a feasible therapeutic method to entail the circumferential coagulation in the tubular tissues in a reliable manner. Abstract : Photothermal treatment of tubular tissue is challenging due to inherent geometry. A basket‐integrated optical device is developed to apply circumferential treatment on trachea by centering a diffuser in the lumen. Ex vivo tracheal testing shows that the concentric irradiation yields the uniform coagulation in the mucosa layer. The proposed device may be a feasible biomedical tool to entail radial photothermal treatment of the tubular tissue in a reliable manner.