Unexpected disseminated histoplasmosis detected by bone marrow biopsy in a solid organ transplant patient. Issue 1 (22nd November 2017)

• Record Type: Journal Article
• Authors: Simon, Caroline T.; Murga‐Zamalloa, Carlos A.; Bachman, Michael A.; Petty, Lindsay A.; Choi, Sarah M.
• Is Part Of: Clinical case reports. Volume 6:Issue 1(2018)
• Page Start: 49
• Page End: 51
• Publication Date: 2017-11-22
• Subjects: Bone marrow -- ferritin -- hemophagocytic lymphohistiocytosis -- histoplasmosis; Medicine -- Periodicals; 616.09
• DOI: 10.1002/ccr3.1282
• Languages: English
• ISSNs: 2050-0904

Abstract

Key Clinical Message: Disseminated histoplasmosis and hemophagocytic lymphohistiocytosis show overlapping features, which require careful contextual interpretation. Histopathologic evaluation can potentially rapidly identify cases of possible histoplasmosis. A high index of clinical suspicion, particularly in endemic areas and in a setting of immunosuppression, is critical to appropriate diagnosis and treatment. Abstract : Disseminated histoplasmosis and hemophagocytic lymphohistiocytosis show overlapping features, which require careful contextual interpretation. Histopathologic evaluation can potentially rapidly identify cases of possible histoplasmosis. A high index of clinical suspicion, particularly in endemic areas and in a setting of immunosuppression, is critical to appropriate diagnosis and treatment.