A chronic very low dose of gamma-rays alters cell adhesion. (1st January 2011)

• Record Type: Journal Article
• Authors: Lacoste-Collin, Laetitia; Jozan, Suzanne; Pereda, Veronica; Courtade-Saïdi, Monique
• Is Part Of: International journal of low radiation. Volume 8:Number 5/6(2011)
• Page Start: 412
• Page End: 428
• Publication Date: 2011-01-01
• Subjects: low-dose rate radiation -- cell adhesion -- adaptive response -- HL60 -- MCF7; Radiobiology -- Periodicals; Radiation -- Health aspects -- Periodicals; Radiation tolerance -- Periodicals; 571.4505
• DOI: 10.1504/IJLR.2011.047185
• Languages: English
• ISSNs: 1477-6545

Abstract

The biological effects of very low doses of ionising radiation are difficult to assess. We previously observed a delay of death by lymphoma in two different mouse strains continuously irradiated ( γ -rays) with a dose rate of 10 cGy year −1 . Cellular mechanisms likely to lead to slowing tumour growth were explored. Human lymphoid and epithelial cell lines (HL60 and MCF7) were irradiated in vitro at very low dose rate of 4 cGy month −1 . Proliferation was not modified in HL60 and MCF7 cells. However, irradiated MCF7 adherent cells showed a lower cell attachment to support partly related to a slight decrease in expression levels of α6 and β4 integrins. We also observed a transient adaptive response during at least two weeks after the beginning of the irradiation in both cell lines. These results demonstrate the ability of tiny amounts of gamma-irradiation to alter cell attachment to support and to induce an adaptive response.