Anti-neuroinflammatory diterpenoids from the endangered conifer Podocarpus imbricatus. Issue 2 (1st February 2018)

• Record Type: Journal Article
• Authors: Hu, Chang-Ling; Xiong, Juan; Xiao, Chen-Xi; Tang, Yu; Ma, Guang-Lei; Wan, Jiang; Hu, Jin-Feng
• Is Part Of: Journal of Asian natural products research. Volume 20:Issue 2(2018)
• Page Start: 101
• Page End: 108
• Publication Date: 2018-02-01
• Subjects: Podocarpus imbricatus -- Podocarpaceae -- endangered plant -- diterpenoids -- anti-neuroinflammation; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2017.1319821
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: Ten diterpenoids including three new abietanes (1 –3 ) were isolated from the twigs and needles of Podocarpus imbricatus, an endangered conifer growing in a Cantonese garden. The new structures were established by means of spectroscopic methods. Among the isolates, 3 β -hydroxy-abieta-8, 11, 13-trien-7-one (5 ), decandrin G (6 ), and 7, 15-pimaradien-18-oic acid (8 ) showed significant anti-neuroinflammatory activities by inhibiting the overproduction of nitric oxide (NO) in lipopolysaccharide (LPS)-stimulated murine BV-2 microglial cells, with IC50 values of 3.7, 11.1, and 4.5 μM, respectively. Abstract :