A systematic review of safety and efficacy of hepatopancreatoduodenectomy for biliary and gallbladder cancers. Issue 1 (January 2016)

• Record Type: Journal Article
• Authors: Zhou, Yanming; Zhang, Zuobing; Wu, Lupeng; Li, Bin
• Is Part Of: HPB. Volume 18:Issue 1(2016)
• Page Start: 1
• Page End: 6
• Publication Date: 2016-01
• Subjects: Liver -- Diseases -- Periodicals; Biliary tract -- Diseases -- Periodicals; Pancreas -- Diseases -- Periodicals; 616.362005
• DOI: 10.1016/j.hpb.2015.07.008
• Languages: English
• ISSNs: 1365-182X

Abstract

Abstract: Objectives: To review the evidence on the safety and efficacy of hepatopancreatoduodenectomy for biliary and gallbladder cancers. Methods: Medline and EMBASE were systematically searched for papers of hepatopancreatoduodenectomy in patients with biliary and gallbladder cancers. Results: Eighteen studies involving 397 patients were reviewed. Major hepatectomy was undertaken in 81.3% of the 397 patients and the R0 resection rate was 71.3%. The morbidity and mortality rates were 78.9% and 10.3%, respectively. The 5-year overall survival rate ranged from 3% to 50% (median = 31%). The 5-year survival rate in patients who underwent curative resection was 18–68.8% (median = 51.3%), and 0% in patients who received non-curative resection. Conclusions: Hepatopancreatoduodenectomy is a challenging procedure with high morbidity and mortality rates. However, this procedure can provide a chance of long-term survival in patients in whom curative resection is feasible.