To die or not to die: Regulatory feedback phosphorylation circuits determine receptor-interacting protein kinase-1 (RIPK1) function. (2nd January 2018)
- Record Type:
- Journal Article
- Title:
- To die or not to die: Regulatory feedback phosphorylation circuits determine receptor-interacting protein kinase-1 (RIPK1) function. (2nd January 2018)
- Main Title:
- To die or not to die: Regulatory feedback phosphorylation circuits determine receptor-interacting protein kinase-1 (RIPK1) function
- Authors:
- Menon, Manoj B.
Gropengießer, Julia
Ruckdeschel, Klaus
Gaestel, Matthias - Abstract:
- ABSTRACT: Complex posttranslational modifications determine the effects of receptor-interacting protein kinase-1 (RIPK1) on cell survival and death. Studies from us and others have revealed a p38 MAPK /MK2-dependent checkpoint in RIPK1 signaling. MAPKAP kinase 2 (MK2) phosphorylates RIPK1 to suppress RIPK1-mediated apoptosis and necroptosis in response to diverse stimuli relevant to inflammation, infection, genotoxic stress and chemotherapy.
- Is Part Of:
- Molecular & cellular oncology. Volume 5:Number 1(2018)
- Journal:
- Molecular & cellular oncology
- Issue:
- Volume 5:Number 1(2018)
- Issue Display:
- Volume 5, Issue 1 (2018)
- Year:
- 2018
- Volume:
- 5
- Issue:
- 1
- Issue Sort Value:
- 2018-0005-0001-0000
- Page Start:
- Page End:
- Publication Date:
- 2018-01-02
- Subjects:
- RIPK1 -- MK2 -- cell death -- signal transduction -- phosphorylation
Tumors -- Periodicals
Neoplasms
Periodicals
616.99 - Journal URLs:
- http://www.tandfonline.com/loi/kmco20#.VyIIeFL2aic ↗
http://www.tandfonline.com/ ↗ - DOI:
- 10.1080/23723556.2017.1396389 ↗
- Languages:
- English
- ISSNs:
- 2372-3556
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 5669.xml