Mesoporous silica-based versatile theranostic nanoplatform constructed by layer-by-layer assembly for excellent photodynamic/chemo therapy. (February 2017)

• Record Type: Journal Article
• Authors: Chen, Wei-Hai; Luo, Guo-Feng; Qiu, Wen-Xiu; Lei, Qi; Liu, Li-Han; Wang, Shi-Bo; Zhang, Xian-Zheng
• Is Part Of: Biomaterials. Volume 117(2017)
• Page Start: 54
• Page End: 65
• Publication Date: 2017-02
• Subjects: Mesoporous silica nanoparticle -- Tumor-target -- Supramolecular photosensitizer -- Dual-modal imaging -- Photodynamic/chemo therapy; Biomedical materials -- Periodicals; Biocompatible Materials -- Periodicals; Biomatériaux -- Périodiques; 610.28
• DOI: 10.1016/j.biomaterials.2016.11.057
• Languages: English
• ISSNs: 0142-9612

Abstract

Abstract: Supramolecular photosensitizers (supraPSs) have emerged as effective photodynamic therapy (PDT) agents. Here, we propose the assembling capacity of supraPSs as a new strategy to construct theranostic nanoplatform with versatile functions aming at high-performance tumor therapy. By coating tirapazamine (TPZ)-loaded mesoporous silica nanoparticles (MSNs) with layer-by-layer (LbL) assembled multilayer, the versatile nanoplatform (TPZ@MCMSN-Gd 3+ ) was obtained with the formation of supraPSs via host-guest interaction and the chelation with paramagnetic Gd 3+ . The TPZ@MCMSN-Gd 3+ could be specifically uptaken by CD44 receptor overexpressed tumor cells and respond to hyaluronidase (HAase) to trigger the release of therapeutics. As confirmed by in vivo studies, TPZ@MCMSN-Gd 3+ showed preferential accumulation in tumor site and significantly inhibited the tumor progression by the collaboration of PDT and bioreductive chemotherapy under NIR fluorescence/MR imaging guidance. Taken together, this supraPSs based strategy paves a new paradigm of the way for the construction of theranostic nanoplatform.