Bio-derived cellulose nanofibril reinforced poly(N-isopropylacrylamide)-g-guar gum nanocomposite: An avant-garde biomaterial as a transdermal membrane. (17th January 2018)

• Record Type: Journal Article
• Authors: Dutta, Koushik; Das, Beauty; Orasugh, Jonathan Tersur; Mondal, Dipankar; Adhikari, Arpita; Rana, Dipak; Banerjee, Rajdeb; Mishra, Roshnara; Kar, Sumit; Chattopadhyay, Dipankar
• Is Part Of: Polymer. Volume 135(2017)
• Page Start: 85
• Page End: 102
• Publication Date: 2018-01-17
• Subjects: Jute -- Cellulose nanofibril -- Guar gum -- N-isopropylacrylamide -- Diltiazem hydrochloride -- In-vitro drug release; Polymers -- Periodicals; Polymerization -- Periodicals; Polymères -- Périodiques; Polymérisation -- Périodiques; 547.7
• DOI: 10.1016/j.polymer.2017.12.015
• Languages: English
• ISSNs: 0032-3861

Abstract

Abstract: The delivery of diltiazem hydrochloride in therapeutical doses has attracted an immense research interest. However, its slower penetration through the transdermal route has stipulated to develop a competent transdermal membrane. Therefore, a nanocomposite based patch was formulated by exploring co-polymer and jute derived nano-cellulose. Poly( N -isopropylacrylamide) was grafted into guar gum (GG- g -PNIPAAm) with different feeding ratios. The co-polymer formation was authenticated by FTIR and 13C NMR spectra. The nanocomposite were prepared by incorporating nanofibre (0.5–2 wt%) into GG- g -PNIPAAm. The structural and morphological studies supported good interactions and presence of nano-cellulose on co-polymer. GG- g -PNIPAAm has showed higher thermostability than guar gum. Moreover, the addition of CNF has improved the thermo-mechanical and barrier properties of the nanocomposite. The nanocomposite containing 1 wt% CNF was found to be best performing. The patch showed in-vitro cyto-compatibility and non-irritant behaviour. The in-vitro release study of best nanocomposite revealed controlled drug release capability with 7.78 and 22.9% after 5 and 20 h, respectively. Graphical abstract: Highlights: Synthesis of cellulose nanofibril from waste jute. Synthesis of guar gum- g -poly( N -isopropylacrylamide) via free radical polymerization. Nanocomposite membrane was formulated by using co-polymer and NCF. Nanocomposite based membrane control and sustains drug release. Nanocomposite membrane is nontoxic and nonirritant.