First report of spumigin production by the toxic Sphaerospermopsis torques-reginae cyanobacterium. (15th December 2015)

• Record Type: Journal Article
• Authors: Sanz, Miriam; Dörr, Felipe Augusto; Pinto, Ernani
• Is Part Of: Toxicon. Volume 108(2015)
• Page Start: 15
• Page End: 18
• Publication Date: 2015-12-15
• Subjects: Sphaerospermopsis -- Spumigin -- HPLC-ESI-QTOF-MS -- Mass spectrometry; Toxins -- Periodicals; Venom -- Periodicals; 615.9
• DOI: 10.1016/j.toxicon.2015.09.019
• Languages: English
• ISSNs: 0041-0101

Abstract

Abstract: High resolution mass spectrometry investigation of an extract of the toxic cyanobacterium Sphaerospermopsis torques-reginae ITEP-024 led to the discovery of four new spumigin congeners. The structures for these peptides were postulated on the basis of accurate mass data and isotopic pattern information of both full scan and product ion spectra. This is the first reported evidence of spumigins on Sphaerospermopsis species. Graphical abstract: Highlights: S. torques-reginae ITEP-024 was studied for secondary metabolite using LC-QTOF-MS/MS. S. torques-reginae ITEP-024 was confirmed as spumigin-producer. These spumigins incorporate hydroxy-(hydroxyphenyl)butyric acid and tyrosine. This is the first reported evidence of spumigins on Sphaerospermopsis species.