[18F]ODIBO: a prosthetic group for bioorthogonal radiolabeling of macromolecules via strain-promoted alkyne–azide cycloaddition. Issue 3 (24th November 2017)

• Record Type: Journal Article
• Authors: Boudjemeline, Mehdi; McNitt, Christopher D.; Singleton, Thomas A.; Popik, Vladimir V.; Kostikov, Alexey P.
• Is Part Of: Organic & biomolecular chemistry. Volume 16:Issue 3(2017)
• Page Start: 363
• Page End: 366
• Publication Date: 2017-11-24
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c7ob02532g
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : [ 18 F]oxadibenzocyclooctyne ([ 18 F]ODIBO) allows for efficient biorthogonal radiolabeling of macromolecules at low concentrations and room temperature via SPAAC. Abstract : A novel prosthetic group for the efficient radiolabeling of macromolecules has been developed. [ 18 F]oxadibenzocyclooctyne ([ 18 F]ODIBO) is synthesized in high radiochemical yield and applied for nearly quantitative conjugation to azide-tagged peptides and proteins at room temperature and low substrate concentrations. The resulting bioconjugates are chemically and radiochemically pure and free of toxic solvents and catalysts.