Genomic analysis of a case of agminated Spitz nevi and congenital‐pattern nevi arising in extensive nevus spilus. (17th December 2017)

• Record Type: Journal Article
• Authors: Porubsky, Caitlin; Teer, Jamie K.; Zhang, Yonghong; Deschaine, Maria; Sondak, Vernon K.; Messina, Jane L.
• Is Part Of: Journal of cutaneous pathology. Volume 45:Number 2(2018)
• Page Start: 180
• Page End: 183
• Publication Date: 2017-12-17
• Subjects: congenital nevus -- genomics -- HRAS -- nevus spilus -- Spitz nevus; Skin -- Diseases -- Periodicals; Dermatology -- Periodicals; 616
• DOI: 10.1111/cup.13082
• Languages: English
• ISSNs: 0303-6987

Abstract

Abstract : Nevus spilus is a melanocytic neoplasm characterized by a tan macular background punctuated by multiple hyperpigmented macules or papules that represent various types of nevi. These include junctional and compound nevi, Spitz nevi, and rarely blue nevi. We report a unique case of widespread, multiple nevi spili giving rise to agminated Spitz nevi and congenital‐pattern compound nevi. We performed genetic analysis to further characterize the mutational profile of this rare entity.