Tadalafil 5 mg Once Daily Improves Lower Urinary Tract Symptoms and Erectile Dysfunction: A Systematic Review and Meta‐analysis. Issue 1 (5th November 2016)

• Record Type: Journal Article
• Authors: WANG, Yilin; BAO, Yiping; LIU, Jie; DUAN, Lijun; CUI, Yuanshan
• Is Part Of: LUTS. Volume 10:Issue 1(2018)
• Page Start: 84
• Page End: 92
• Publication Date: 2016-11-05
• Subjects: erectile dysfunction -- lower urinary tract symptoms -- meta‐analysis -- randomized controlled trial -- tadalafil; Urology -- Periodicals; Urologic Diseases -- Periodicals; Urinary Tract Physiological Phenomena -- Periodicals; 616.62
• DOI: 10.1111/luts.12144
• Languages: English
• ISSNs: 1757-5664

Abstract

Abstract : Objectives: We carried out a systematic review and meta‐analysis to assess tadalafil 5 mg once‐daily for the treatment of lower urinary tract symptoms (LUTS) and erectile dysfunction (ED). Methods: A literature review was performed to identify all published randomized double‐blind, placebo‐controlled trials of tadalafil 5 mg once‐daily for the treatment of LUTS and ED. The search included the following databases: MEDLINE, EMBASE, and the Cochrane Controlled Trials Register. The reference lists of the retrieved studies were also investigated. Results: Thirteen publications involving a total of 3973 patients were used in the analysis, including 13 RCTs that compared tadalafil 5 mg once‐daily with placebo. We found that tadalafil 5 mg once‐daily was effective in improving LUTS suggestive of BPH and treating ED over 12 weeks in our meta‐analysis. Total International Prostate Symptom Score (IPSS) (SMD = − 2.02, 95% CI = − 2.52 to −1.53, P < 0.00001); Benign Prostatic Hyperplasia Impact Index (BPH‐II) (SMD = −0.58, 95% CI = −0.84 to −0.33, P < 0.00001); International Index of Erectile Function‐erectile function (IIEF) domain (standardized mean difference [SMD] = 5.18, 95% confidence interval [CI] = 4.13–6.23, P < 0.00001) indicated that tadalafil 5 mg once‐daily was more effective than the placebo. Safety assessments included discontinuations due to adverse event (odds ratio (OR) = 1.79, 95% CI = 1.12–2.85, P = 0.01) indicated that tadalafil 5 mg once‐daily was well tolerated. Conclusions: This meta‐analysis indicates that tadalafil 5 mg once‐daily to be an effective treatment for LUTS and ED with a low occurrence of side effects.