Associations between a parental history of premature cardiovascular disease and coronary artery calcium and carotid intima-media thickness: the Coronary Artery Risk Development In Young Adults (CARDIA) study. (May 2014)

• Record Type: Journal Article
• Authors: Wilkins, John T; Gidding, Samuel; Liu, Kiang; Ning, Hongyan; Polak, Joseph F; Lloyd-Jones, Donald M
• Is Part Of: European journal of preventive cardiology. Volume 21:Number 5(2014)
• Page Start: 601
• Page End: 607
• Publication Date: 2014-05
• Subjects: Carotid intima-media thickness -- coronary artery calcium -- family history of premature cardiovascular disease; Cardiovascular system -- Diseases -- Prevention -- Periodicals; Cardiac patients -- Rehabilitation -- Periodicals; 616.12
• DOI: 10.1177/2047487312462801
• Languages: English
• ISSNs: 2047-4873

Abstract

Background: It is unclear if associations between a parental history of premature CVD (pCVD) and subclinical atherosclerosis are attenuated by adjustment for long-term risk factor levels through middle adulthood. Design: Prospective community-based cohort study. Methods: CARDIA participants who attended the year-20 exam ( n = 2283, mean age 45 years) were grouped by pCVD status: maternal only, paternal only, any parental, and no parental history (referent). We used separate logistic regression models, adjusted for average risk factor levels over a 20-year follow up to assess associations of parental pCVD and subclinical atherosclerosis in offspring. Results: White participants with any parental history of pCVD had a higher odds of coronary artery calcium (CAC) >0 than participants with no parental history (OR 1.55, 95% CI 1.01–2.37). This was largely driven by the association of a paternal history of pCVD with CAC >0 (OR 2.15, 95% CI 1.42–3.23), which was minimally attenuated by multivariable adjustment (OR 2.09, 95% CI 1.31–3.32). Similarly, adjusted associations between parental pCVD and intima-media thickness (IMT) >90% were observed in white participants with a paternal history of pCVD (OR 1.93, 95% CI 1.10–3.39) and any parental history pCVD (OR 1.67, 95% CI 1.02–2.74). No significant associations between a parental history of pCVD and the odds of subclinical atherosclerosis were observed in black participants. Conclusions: Parental pCVD is independently associated with early development of subclinical atherosclerosis; these associations may be race-specific for participants in their fifth decade of life.