Fabrication of gelatin-poly(epichlorohydrin-co-ethylene oxide) fiber scaffolds by Forcespinning® for tissue engineering and drug release. (24th October 2017)

• Record Type: Journal Article
• Authors: Mamidi, Narsimha; Leija Gutiérrez, Héctor Manuel; Villela-Castrejón, Javier; Isenhart, Lucas; Barrera, Enrique V.; Elías-Zúñiga, Alex
• Is Part Of: MRS communications. Volume 7:Number 4(2017)
• Page Start: 913
• Page End: 921
• Publication Date: 2017-10-24
• Subjects: Materials -- Periodicals; 620.11
• DOI: 10.1557/mrc.2017.117
• Languages: English
• ISSNs: 2159-6859

Abstract

Abstract: Abstract : Gelatin/poly(epichlorohydrin-co-ethylene oxide) [GL : PECO] composites are synthesized in a one-step process by the incorporation of elastic PECO and diclofenac. [GL : PECO] fibers are prepared by Forcespinning ® . GL : PECO fibers are capable of diclofenac, by conjugation via a labile amide linkage. Fourier transform infrared spectroscopy (FTIR) results confirmed the chemical reactions and hydrogen bonds between gelatin, PECO, and diclofenac. Diclofenac drug release from GL : PECO fibers are measured for 15 days and prolonged drug release is observed. The cell viability is studied with NIH/3T3 and excellent results are observed. The sustained drug release and cytotoxicity results reveal that GL : PECO fibers could be promising substitutes for skin tissue engineering, wound healing, and drug delivery.