Paradoxical immune reconstitution inflammatory syndrome associated with cryptococcal meningitis in China: a 5-year retrospective cohort study. (April 2015)

• Record Type: Journal Article
• Authors: Yan, S.; Chen, L.; Wu, W.; Li, Z.; Fu, Z.; Zhang, H.; Xue, J.; Hu, Y.; Mou, J.; Fu, C.
• Is Part Of: Clinical microbiology and infection. Volume 21:Number 4(2015:Apr.)
• Page Start: 379.e11
• Page End: 379.e14
• Publication Date: 2015-04
• Subjects: ART -- cryptococcal meningitis -- HIV/AIDS -- IRIS -- predictors; Medical microbiology -- Periodicals; Diagnostic microbiology -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 616.01
• DOI: 10.1016/j.cmi.2014.11.011
• Languages: English
• ISSNs: 1198-743X

Abstract

Abstract: We performed a retrospective cohort study of hospitalised cryptococcal meningitis (CM) patients at a single centre to evaluate the clinical epidemiological features of paradoxical cryptococcal-related immune reconstitution inflammatory syndrome (CM-IRIS) in a setting in China. A total of 154 AIDS patients with CM were involved, and 17.5% experienced IRIS at a median of 27 days after initiation of antiretroviral therapy (ART). Overall, 3 deaths were directly attributed to IRIS. The occurrences of CM-IRIS were independently associated with the pre-ART CD4 + count, pre–C-reactive protein level, and the timing of ART initiation.